I made a thread about the same issue over att SS.org but didn't get any replies! Figured I'd try over here!
So basically I'm using my POD X3 for effects with my Triaxis->2:90->Rectifier 2x12 cab-rig! Since I don't have a Noise gate at the moment I want to use the one in the POD X3 as well as other effects like delay and different kinds of modulations! Using the 4 cable method will make it possible to have these effects in the right place in the signal chain.
My question is what settings I should use on the PODX3 to make sure the tone is coloured the least when it goes through the POD! I'm sure some of you have done this so please help me out!
Just turn off anything you're not using (i.e. amp sims, cab sims, etc.) and that's the best you can do.
Also, you can't 4-cable a POD X3 unless it's the Live or Pro version. The bean doesn't have an effects loop, the others do.