Short version, Behringer BCR2000 (Cheapish MIDI controller, about $200) plus this guy's product = awesome. Basically you assign the knobs on the BCR2000 to any of the parameters in the Axe-Fx, so that you can tweak just about every part of every preset on the fly without having to dive through menus.
28 effect types / 32 parameters apiece.
[VIDEO]http://www.youtube.com/watch?v=x0Dv-ySGUJI]Preview of the MidyAX by LeafONICs - part 1/2 - YouTube[/VIDEO]
What he's doing with the looper is recording a quick guitar clip, then using the BCR to page through the different blocks in the Axe-Fx, and then tweaking the sound there (changing amp/cab, adding effects, etc). In addition to the knobs, the BCR has a bunch of buttons, so you can one-poke toggle blocks off and on as well.
Thread on FAS here:
Preview of the MidyAX - A new tool to enhance the AXE-FX experience
This is the Behringer unit:
[VIDEO]http://www.amazon.com/Behringer-BCR2000-B-Control-Rotary-Controller/dp/B000CZ0RJC]Amazon.com: Behringer BCR2000 B-Control Rotary USB/MIDI Controller: Musical Instruments[/VIDEO]
This could fix many of the tweakability-on-the-fly issues I have with the AFX. Interesting.