TS are not hum-cancelling. Technically, a hum-cancelling single-coil is not a single-coil... I don't think you really need to go that route, personally. A well-made single-coil pup will reject a lot of noise. The nature of the beast, though, is that it will carry more noise than a humbucker. Going to a hum-cancelling design tends to defeat the excellent cleans, though. It's not that they're bad, but the pickups tend to be more "muscular" and middy, which takes away some of that single-coil charm. YMMV.
I've read that Adrian Smith uses TS pickups, but that he has something much hotter in the bridge. I think Dave Murray has them too. One of them actually runs like a 50' cable on stage because he doesn't like wireless, so that's BEGGING for noise pickup and obviously it works fine for him...
I know you're a big EMG fan, but in my opinion lower-output passive pickups sound much clearer under high gain than higher-output passive pickups. General rule of thumb, broadly speaking, YMMV, etc. etc. FWIW, EMG SA's are very nice pickups with pretty good clean tones.
You also wouldn't want to match up something like TS (maybe 6.5k resistance in the neck position) with a 25k coil in the bridge. Too much volume disparity.
Listen to the clean tones on this Trilogy Suite pickup set, then compare it to the Slow Hand set under Vintage Hot, and then some of the "vintage" output pickups to see what happens to clean tones as you pump up the midrange thickness.