Just had an idea last night...
In my SSH Jackson, I've currently got an X2N in the bridge and stock middle and neck pickups. My main idea for the other two positions is a Chopper or Cruiser in the neck, then something from the Area series in the middle.
Last night though, I was thinking about adding an Air Norton S to the middle position and wiring it to split in position four, so you'd get...
Bridge and middle humbuckers
Middle and neck singles
Seems like it'd be really versatile. I really liked the tone of the middle pickup on James' SC607 for alternate picking, and I only really use the middle single coil in parallel with the other pickups at the moment.
Or am I just being weird?
Wirelessly posted (like MAGIC!)
Instead of a neck humbucker in the middle position, try a bridge pickup.