I've seen many, many threads on this over the years but never from people I actually trust to know what they are talking about.
I don't run a lot of gain on my 6505 (about 6.5 for my passives) but I like a very active-like pickup - something tight and punchy, with a quick response and happy to snarl. I run a lot of mids to punch through and not as much bass as you might think. I'm looking for all of that and good note-to-note definition () when playing convoluted chords low down. Lead tones aren't really relevant as I have my neck pup for that.
Dimarzio or bust. Has to be green.