The latest version of the MOTU driver that came out on 5/2 allows you to control the volume using the keyboard volume keys. The old driver would disable them, and the only way to turn the unit up/down was with the hardware button.
It works with my 828 MkII, as well as the Mk3, 8Pre, and probably a bunch of others as well.
Fuck yes! This is my biggest gripe with the MOTU.
Can you independently control headphone and main outputs or does it just use which ever is selected?