I wonder how the Synergy amps will do - I had a Randall Lynchbox back in the day and the modules were a cool idea, but I wasn't thrilled with how they sounded (I bought it used and wondered if someone had tried to mod the circuits). I do miss that green alligator tolex.
I like how these are actually designed with the manufacturers and licensed - the Randall used Line 6 style knock-off names like Treadplate.
All in all I think it's a cool idea. I like the idea of buying one amp and being able to get a drastically different tone for a few hundred bucks and not a lot of extra space.