I sometimes had a second OD sitting next to the first. One for rhythm that might have a bit of a bass cut like a tube screamer, and a second for leads with more a flat EQ like a Klone with the Drive set a bit higher.
Or, yeah, setup the Orange channel for leads, and the Red for rhythms!
Also, make sure your Output is at least up to 12:00, and use the channel Masters as overall volume control. I think this helps the responsiveness of the amp in general, and helps to make the clean channel actually useable