My main guitar is a Les Paul with Duncan Seth Lovers. It gives me what I'm looking for for rock and Metal. I also am enjoying my Stratocaster (SSS), and like the sounds that Blackmore, YJM, and Uli Roth get. I never see myself using a Strat as my primary Metal guitar, but I'm interested in what pickups work well when overdriven to heavy rock levels, especially for Rhythm work - good lead tone is easier.
I don't use modern super high gain, but hover around '70s - '80s levels using a Marshall Vintage Modern 50w Combo or a DSL50 head. Sometimes I'll goose them with a boost or OD pedal, but that's about all I use.
I wouldn't use the Strat for thrash or death metal work, but classic '70s hard rock, Doom Stuff, NWOBHM and classic metal styles. I'd still like it to clean up well.
Not looking for hot rails or mini humbuckers. Interested in keeping the unique characteristics of single coils. I've got humbuckers around in other guitars for when I want humbuckers.
So, who's using singles and what pickups and setup work well for you (or them - other musicians you know of or listen to)?