Dark Wolf used to tune his RG2027 with a 25.5" scale length to drop C with a low F on the seventh string. It just takes the right setup and strings.
Yup.
And... it worked, played, and sounded just fine. I tune to A standard nowadays, and have for years. Wrote all new material, yada yada. But I used to rock the drop C/drop F tuning, and even with a 25.5" scale guitar, it sounded just fine. (No, I wasn't just chugging along in F all the time. I like the chord voicing you get with that tuning, and having low C/low F made sense to me mentally.) Worked fine on the Lo Pro trem, too. A lot of the naysayer stuff is just bullshit, honestly. Yeah, I'm a bit of a tweaker, but I never had any major problems with this setup., I used it for like 5 years or so.
Elixir .068 string (still use that same string in A)
Very tight distortion
EQ
Tight pickups (mostly a Blaze bridge or a D Sonic 7 back then)