You may be developing tendonitis from playing so fast for so long. Take at least a week off playing and see if things start feeling any better. If it's actually tendonitis you're gonna have to take a longer break, though.
I think I have the same issue as you do with my right hand--If I palm mute fast stuff for too long it starts to hurt, but I can go a long time doing the same thing without palm muting. What kind of bridge does your guitar have? If it's a hardtail that's low to the body, it can make that issue worse for some people. On guitars like that it's more comfortable for me to play with the neck pushed a bit further away from me. Experiment with the angle of your wrist and see what feels the least tense
I think I have the same issue as you do with my right hand--If I palm mute fast stuff for too long it starts to hurt, but I can go a long time doing the same thing without palm muting. What kind of bridge does your guitar have? If it's a hardtail that's low to the body, it can make that issue worse for some people. On guitars like that it's more comfortable for me to play with the neck pushed a bit further away from me. Experiment with the angle of your wrist and see what feels the least tense